And your patients are counting on you to know it as well. Haskins, sampling and storage of blood for ph and blood gas analysis j. To obtain free cmecmle credits click on earn ce credits under continuing education on the left side of the screen. Simple algorithm of arterial blood gas analysis to ensure consistent, correct and quick responses. Certifying boards love testing on this stuff, especially mixed acid base disorders, that will often be missed without knowing what youre doing. When there is just one simple acidbase disorder present, the traditional concept is sufficient. Ryan killian, pharmd, bcps assistant professor clinical pharmacy.
By understanding the basic principles of acidbase physiology, the inter pretation of. Lithium toxicity, multiple myeloma with production of cationic paraproteins. These conditions can be categorized as acidoses or alkaloses and have a respiratory or metabolic origin, depending on the cause of the imbalance. Compensation there are also some formulas that allow you to calculate whether the compensation that occurs is an appropriate response to the primary process or whether this compensation actually reflects the presence of a second primary process. The late peter stewart developed an approach to the analysis of acid base disturbances in biological systems based on basic physical. Acidbase made easy the differential diagnoses for acidbase problems can be reduced to a workable few by using a minimal amount of laboratory data. Apr 21, 2019 arterial blood gas analysis is used to determine the adequacy of oxygenation and ventilation, assess respiratory function and determine the acidbase balance. Acidbase disorders principles and practice of hospital. It provides nurses and other health professionals, who are less than familiar. In addition, you will find tables that list commonly encountered acidbase disorders. Learning objectives the clinician after participating in the roundtable will be able to. Pdf facing acidbase disorders in the third millennium. Complex or mixed acidbase disturbances involve more than one primary process.
Mixed metabolic alkalosis and respiratory acidosis. Generally, acidbase disorders are analyzed according to the socalled traditional concept, which includes the determination of the standard base excess sbe, bicarbonate concentration in the plasma hco 3. Jun 04, 2014 the stewart approach, based on physicochemical principles, is a robust physiological concept that can facilitate the interpretation and analysis of simple, mixed, and complex acidbase disorders, thereby allowing better diagnosis of the cause of the disturbance and more timely treatment. However, in the hospital setting, especially the critically ill, it is crucial that patients with acid base disturbances be quickly identified and the abnormality be accurately interpreted.
Metabolic and respiratory acidbase disorders occur as single and mixed entities. I understand basics of abgbmp and acid base rules w a primary do w compensations or two primary disorders. Mixed acid base disorders 2,3 are those in which two or more primary aetiological disorders are present simultaneously. Mixed acid base disorder classic boards type example. Acidbase disorders knowledge for medical students and.
A guide to interpreting acidbase disorders article pdf available in hospital pharmacy 4310. Basic laboratory tests basic urine tests urinalysis test alternative names occurunits usual normal range examples of conditions in which abnormal values ph, urine ph ph units 4. Metabolic acidosis and metabolic alkalosis objectives by the end of this chapter, you should be able to. Identify etiologies of anion gap and nonanion gap acidosis. The first step in acidbase analysis is to identify all abnor malities. In these mixed disorders, values may be deceptively normal. Simple acidbase disorders are caused by the four primary acidbase disturbances, metabolic or respiratory in origin, with an anticipated compensatory change9 table 1. Complex acidbase disorder an important clinical pearl to differentiate between simple and mixed acidbase disorder is. In management of acidbase disorders, it is most important to recognize and treat the underlying etiology. Jul 05, 2016 6232016 simple and mixed acid base disorders. This discussion does not include some methods, such as analysis of base excess or stewarts strong ion difference.
Disorders of acidbase balance can create complications in many disease processes, and occasionally underlying disorders may be so severe. Following wellestablished principles and formulas, the presenter will help you resolve common acidbase problem cases. Thus, it is important when evaluating acidbase disorders to determine whether changes in p co 2 and hco 3. I am going to present a structured approach to the identification of acid base disorders based on a set of welldefined rules. The four simple acid base disorders metabolic acidosis, respiratory acidosis, metabolic alkalosis, and respiratory alkalosis are discussed in this article. Diagnosis and treatment of simple acidbase disorders. Simple algorithm of arterial blood gas analysis to. Analysis of the arterial blood gave the following values. When blood gas analysis is carried out, the partial pressure of co2 pco2 and the ph are each measured using. If you are an internist or planning on becoming a hospitalist, i highly recommend studying this stuff until you can figure it out in your sleep. Acidbase pathophysiology can be separated into metabolic or respiratory acidosis. Additional supportive therapies may be warranted depending on severity. An acidbase disorders analysis with the use of the stewart. Michael chansky, md, facep acid base disorders 3 iii.
Open access simple algorithm of arterial blood gas analysis to ensure consistent, correct and quick responses. Many physicians are intimidated by the complexity of acid base analysis, as multiple, partially offsetting disorders can be challenging to diagnose. This article is intended to provide an introduction to the physiology of acid base balance and the many pathological conditions that are associated with disturbance of that balance. Algorithm to determine simple acidbase disorders helpful hints o compare hco3on abg and bmp to verify accurate lab values o abg and bmp results should be drawn close to the same time when comparing values o use bmp hco3value when possible because hco3on abg is a calculated value respiratory expected 2 acidosis ph acidbase disorders. Disorders of acid base balance an overview sciencedirect. The following sixstep process helps ensure a complete interpretation of every abg. The ability to diagnose and treat acid base disorders is an important component in the practice of the nutrition support clinician. These data provide information regarding potential primary and compensatory processes that affect the bodys acidbase buffering system. An introduction to acidbase balance in health and disease. We start with some acidbase disorder definitions and then provide a series of case vignettes to illustrate the key points. A systematic approach should be used to evaluate acidbase disorders.
Many methods exist to guide the interpretation of the abg. Basic laboratory tests basic urine tests urinalysis. Acid base disorders made so easy even a caveman can do it lorraine r franzi, mshsm, rd, ldn, cnsd nutrition support specialist university of pittsburgh medical center pittsburgh, pa i. Pdf the accurate interpretation of laboratory tests in patients with acidbase. A complete understanding of the basic principles of metabolic. Acidbase balance educational commentary is provided through our affiliation with the american society for clinical pathology ascp.
However, as the concept does not attach importance to plasma bicarbonate. In what follows, the traditional and stewart formulations will be examined in detail as they relate to 1 the acidbase behavior of simple and complex solutions in vitro, 2 the cellular transport of ions between body. However, i remember seeing some triple acid base problems in the past and couldnt identify the 3 disorders in the problems. Facing acidbase disorders in the third millennium the. Analysis of a patients acidbase disorder includes identification of the primary disorder, calculation of the anion gap ag, evaluation. The calculated osmolality can be simply derived by. In this article, we aim to provide the reader with an overview of the key concepts necessary for developing a good working understanding of acid base disorders that commonly present in clinical medicine. Arterial blood gas analysis is used to determine the adequacy of oxygenation and ventilation, assess respiratory function and determine the acid base balance. Disorders of acidbase balance can create complications in many. Simple algorithm of arterial blood gas analysis to ensure. The respiratory contribution to a change in blood ph can be determined by measuring the partial pressure of carbon dioxide pco 2 in blood, and the metabolic component can be determined. Primary disorder alkalemia metabolic alkalosis high hco 3 respiratory alkalosis low pco 2 acidemia metabolic acidosis low hco 3 respiratory acidosis high pco 2 ph pco 2 hco 3 7.